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TESTIMONIALS

What others are saying about our technologies

 
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"AT THE ONCOIMMUNOLOGY UNIT OF NAVARRABIOMED WE DEVELOP LENTIVIRUS-BASED CANCER IMMUNOTHERAPIES. TO ACCELERATE OUR RESEARCH, WE NEED A FAST, REPRODUCIBLE, AND EASY-TO-USE VIRUS PURIFICATION METHOD. WE TESTED CAPTUVIR TO PURIFY A 100 MILLILITERS SAMPLE OF 0.45 µm-FILTERED LENTIVIRUS PREPARATIONS BOTH WITH AND WITHOUT FCS. COMPARED TO OTHER PURIFICATION METHODS SUCH AS PRECIPITATION OR CENTRIFUGATION THAT TAKE US ALMOST ONE DAY TO PERFORM, CAPTUVIR ALLOWED US TO CONCENTRATE OUR LENTIVIRUSES AROUND TEN TIMES WITH UP TO 70% RECOVERY IN ONLY ONE HOUR.

WE PARTICULARLY LIKED THE FACT THAT USING CAPTUVIR WAS SIMPLE AND THE PURIFICATIONS WERE REPRODUCIBLE.

WE WILL CONTINUE USING CAPTUVIR, ALSO FOR LARGER SAMPLE VOLUMES."

DR. GRAZYNA KOCHAN AND DR. DAVID ESCORS MURUGARREN,

HEADS OF THE ONCOIMMUNOLOGY GROUP AT NAVARRABIOMED

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"AT THE COPENHAGEN HEPATITIS C PROGRAM (CO-HEP) AT COPENHAGEN UNIVERSITY HOSPITAL, HVIDOVRE, WE ARE DEVELOPING INACTIVATED COVID-19 VACCINES. IN ORDER TO TEST THE EFFICACY OF OUR VACCINES IN ANIMALS, WE REQUIRE A ROBUST PURIFICATION AND CONCENTRATION METHOD THAT DOESN'T COMPROMISE THE BIOLOGICAL INTEGRITY OF THE PRODUCT AND THAT CAN COPE WITH THE RELATIVELY LARGE BATCH VOLUMES WE PRODUCE. 

USING CAPTUVIR, 300 MILLILITERS OF OUR INACTIVATED SARS-COV-2 PARTICLES WERE PURIFIED IN ONE HOUR USING A UNIVERSAL PROTOCOL AND SUCCESSFULLY TESTED IN ANIMALS. THANKS TO THESE ENCOURAGING RESULTS, AN ADDITIONAL 4.5 LITERS OF OUR VIRUS HARVESTS WERE PURIFIED WITH CAPTUVIR FOR FURTHER ANIMAL TESTING. 

WE BELIEVE THAT CAPTUVIR'S SXC TECHNOLOGY PROVIDES A SIGNIFICANT IMPROVEMENT OVER OTHER PURIFICATION METHODS, SUCH AS SUCROSE GRADIENTS, THAT ARE POORLY SCALABLE, SLOWER, AND SHOW LOW PRODUCT RECOVERY.

WE FEEL THAT CAPTUVIR WAS A CRITICAL TOOL THAT ALLOWED US TO ACCELERATE PRE-CLINICAL TESTING OF OUR VACCINE CANDIDATES AND WE RECOMMEND IT FOR THE PURIFICATION OF HUMAN CORONAVIRUSES."

PROF. JUDITH GOTTWEIN, MD, DR. MED

CO-HEP, DEPT. OF INFECTIOUS DISEASES, COPENHAGEN UNIVERSITY HOSPITAL, HVIDOVRE AND DEPARTMENT OF IMMUNOLOGY AND MICROBIOLOGY, FACULTY OF HEALTH AND MEDICAL SCIENCES OF COPENHAGEN

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"IN THE BIOPROCESS ENGINEERING GROUP AT THE MAX PLANCK INSTITUTE IN MAGDEBURG, GERMANY, WE ARE WORKING ON CELL CULTURE-BASED PRODUCTION OF VIRAL VACCINES AND VIRAL VECTORS, BUT ALSO ON GENETIC ENGINEERING OF VIRUS-CELL PRODUCTION SYSTEMS.

ONE PARTICULAR FOCUS ARE VIRAL DEFECTIVE INTERFERING PARTICLES (DIPs) THAT MAY BE USED AS AN ANTIVIRAL. THE ANTIVIRAL EFFICACY, HOWEVER, STRONGLY DEPENDS ON THE CONCENTRATION USED. 

WE USE CAPTUVIR VERY FREQUENTLY, IN PARTICULAR, TO CONCENTRATE OUR DIP PRODUCT DERIVED FROM CELL CULTURE-BASED PRODUCTION, RESULTING IN A APPROX. 10–20-FOLD INCREASE IN DIP CONCENTRATIONS. USING OUR PREPARATION, WE WERE ABLE TO SHOW THAT MICE CAN BE RESCUED FROM AN OTHERWISE LETHAL DOSE OF INFECTIOUS VIRUS BY CO-ADMINISTRATION OF THE CONCENTRATED, PURIFIED DIP MATERIAL. IN ADDITION, SARS-COV-2 REPLICATION WAS COMPLETELY ABROGATED BY TREATMENT WITH THE CONCENTRATED PRODUCT IN VITRO.

DUE TO THIS ENCOURAGING RESULTS, WE WILL CONTINUE TO USE CAPTUVIR IN OUR FOLLOW-UP PROJECTS."

DR.-ING. SASCHA KUPKE

TEAM LEADER MOLECULAR BIOLOGY, BIOPROCESS ENGINEERING GROUP

MAX PLANCK INSTITUTE FOR DYNAMICS OF COMPLEX TECHNICAL SYSTEMS

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AT THE POLISH STEM CELL BANK (PBKM) WE ARE USING CAPTUVIR FILTERS TO PURIFY AND CONCENTRATE SAMPLES CONTAINING VIRAL PARTICLES THAT ARE USED FOR THE DEVELOPMENT OF CELL AND GENE THERAPIES. USING THE CAPTUVIR FILTERS WE WERE ABLE TO CONCENTRATE, PURIFY AND OBTAIN HIGH RECOVERIES (>50%) OF FUNCTIONAL VIRUS PARTICLES.

THESE RECOVERED VIRAL PARTICLES WERE THEN SUCCESSFULLY USED TO TRANSDUCE HUMAN T-CELLS WITH HIGH TRANSDUCTION EFFICIENCIES (>50%).

WE ARE IMPRESSED HOW EASY IT IS TO USE THESE FILTERS AND THAT OUR RESULTS USING THEM HAVE BEEN EXTREMELY REPRODUCIBLE.

POLISH STEM CELL BANK (PBKM)